"Fasting is the first principle of medicine"-Rumi

Disclaimer:

Informasi dalam blog ini tentang intermittent fasting (IF) dan diet ketogenik BUKAN bertujuan untuk menggantikan nasihat, konsultansi, diagnosis dan rawatan dari ahli perubatan yang bertauliah. JANGAN berhenti dari sebarang ubat atau follow-up tanpa pengetahuan doktor anda!

Wednesday 13 February 2019

Intermittent Fasting & Longevity

P/S: Please turn off online radio volume at right hand corner of page

 




The main 3 nutrient sensors of the human body, which is similar to most animals are:
  1. mTOR
  2. AMPK
  3. Insulin








Most of these interventions affect one or more of these pathways. With TOR, less is more. Blocking mTOR improves protein handling, increases autophagy and enhances stem cell function. 

That is, from all the animal research, increased health span depends not on having more nutrients, it is having less. Increased longevity depends on decreasing the nutrient sensors (lower mTOR and insulin, higher AMPK) at least periodically.

This is fascinating, because the most ancient dietary intervention is fasting – a clear form of decreasing nutrient-sensing pathways. Humans have used fasting (or cleansing, detoxification, purification or whatever you call it) as a method of increasing wellness since antiquity. Benjamin Franklin, kind of a smart guy, said 
“The best of all medicines is resting and fasting”.
Decreased nutrients sensors
Compared to other dietary interventions, intermittent fasting appears to be far more powerful because alone has the ability to affect all 3 nutrient sensors simultaneously, as well as stimulate autophagy and mitophagy. mTOR is sensitive to dietary protein. Insulin is sensitive to proteins and carbohydrates. So eating a pure fat diet (not realistic) may lower mTOR and insulin, but will not be able to raise AMPK, since that senses the energy status of the cells. If you are eat a very high-fat diet (ketogenic) your body will still be able to metabolize this to energy – generating ATP and lowering AMPK. Only 2 of the 3 nutrient sensing pathways have been alerted. Only complete restriction of nutrients will have this effect (ie. fasting).




.

1 comment:

  1. Cell Cynergy Nutrition was created with one purpose in mind, to help you to maximize your Health span. Health span is the length of time a person lives in optimal health and free from serious disease. Lifespan, in contrast, simply refers to the number of years a person lives.

    ReplyDelete

Sekapur sirih

Assalamualaikum dan salam sejahtera Blog ini ditubuhkan untuk mengumpul dan menyebarkan info-info tentang RDO (Reverse Diabetes/Ob...

Most popular posts

 
Reverse Diabetes/Obesity (RDO)
Closed group · 2,965 members
Join Group
RDO Protocol.. Terbukti berkesan utk reverse masalah berat badan terlebih, kencing manis, darah tinggi, kolesterol tinggi dll... Tanpa ubat Tanpa sup...
 

Interesting youtube videos (IF & keto)

calculate!




Total Pageviews